Advanced Technology & Industrial Co., Ltd
Catalogue - Novelties
NEW BUILDING BLOCKS, SCAFFOLDS AND ADVANCED INTERMEDIATES

FASTER TO MARKET
Enhance the productivity and innovativeness of your Structure-Activity Relationship (SAR) studies with new tools from Acros Organics.

Acros Organics is pleased to offer the medicinal chemist a diverse range of scaffolds, building blocks and advanced intermediates, coupling agents, acids, bases, and solvents to help you attain results faster and more cost effectively.

COMPETITIVE OPPORTUNITIES
Expand your pipeline rapidly and competitively with these new offerings from Acros Organics.
These unique molecules offer the following benefits:

  • Advanced, rigid structures promise interesting binding properties
  • Documented potential for pharmacological activity
  • Multifunctional for synthetic diversity
  • Orthogonally protected for regioselective derivatization
  • Exotic, elegant structures allow for the design of new, “lean” target molecules

COST EFFECTIVE
Acros’s SAR building blocks are cost effective and convenient. Our off-the-shelf building blocks save you valuable prep time, and our highly competitive pricing makes one-stop shopping a cost-saving proposition.

A selection of our latest additions of scaffolds, building blocks and advanced intermediates follows in two sections:

  • I. Amino Acids Advanced Intermediates.
  • II. Chiral Building Blocks, Scaffolds and Advanced Intermediates.

I. AMINO ACIDS ADVANCED INTERMEDIATES
To complement our broad selection of Boc- and Fmoc-protected natural amino acids, we recently added a collection of new building blocks to our product offering. These building blocks have unique structures specifically designed for synthetic flexibility. They are listed in the next pages in the following order.

  1. Piperidinyl Amino Acids
  2. Tetrahydropyran and tetrahydrothiopyranyl amino acids
  3. 2-Amino-3-piperidin-4-yl propionic acids
  4. 3-Amino-3-arylpropionic acids

II. CHIRAL BUILDING BLOCKS, SCAFFOLDS, AND ADVANCED INTERMEDIATES
Through a recent collaboration with Chirotech, a leader in chirality and the application of technology, Acros Organics has recently added a highly valuable and unique selection of chiral scaffolds, building blocks and advanced intermediates to its product range. This Acros Organics - Chirotech portfolio is sorted in the next pages as follows. Entries within each subfamily are listed by order of increasing molecular formula. For additional chiral building blocks and intermediates please consult our alphabetical catalogue listing, our internet site, or your Chirals brochure.

Scaffolds

Building Blocks and Advanced Intermediates

AMINO ACIDS ADVANCED INTERMEDIATES

Piperidinyl Amino Acids
Combines the structural characteristics of isonipecotic acid, nipecotic acid, 2,4-diaminobutyric acid (DABA), and 3-aminocyclohexanecarboxylic acid (ACHC). Nipecotic acid, DABA, and ACHC are substrate-competitive inhibitors of the neuronal GABA uptake system.

(1) Jacobsen, P. et al; Potential GABA Uptake Inhibitors. Synthesis and Relative Stereochemistry of Some Aminopiperidine Carboxylic Acids; Acta Chemica Scandinavica B 1980, 34, 319-326.
(2) Bagley, J. R. et al; New 1-(Heterocyclylalkyl)-4-(Propionanilido)-4-Piperidinyl Methyl Ester and Methylene Methyl Ether Analgesics; Journal of Medicinal Chemistry 1991, 34, 827-841.
(3) Heimgartner, H. et al; Novel Heterospirocyclic 3-Amino-2H-azirines as Synthons for Heterocyclic a-Amino Acids; Helvetica Chimica Acta 1997, 80, 1528-1554.
Name Reference
N-Boc-amino-(4-N-Boc-piperidinyl) carboxylic acid
[189321-65-1]		 36045
4-N-Boc-1,1-amino-piperidinyl carboxylic acid
[183673-71-4]		 36038
N-Fmoc-amino-(3-N-Boc-piperidinyl) carboxylic acid
[189321-65-1]		 36051
N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid
[183673-66-7]		 36037

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Tetrahydropyran and tetra-hydrothiopyranyl amino acids
Tetrahydropyran and tetrahydrothiopyranyl amino acids are potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase.
S-adenosylmethionine synthetase catalyses the reaction of ATP and L-methionine to yield S-adenosylmethionine (AdoMet), pyrophospate, and orthophosphate. AdoMet is utilized by methyltransferases for the methylation of RNA, DNA, histones, proteins, polysaccarides, steroids, and numerous other metabolites. The rational design of methylation inhibitors based on the inhibition of enzymes involved in AdoMet metabolism has attracted the attention of medicinal chemists in the search for antitumor and antiviral agents.

Guillerm, G.et al,; A New Series of Cyclic Amino Acids as Inhibitors of S-Adenosyl L-Methionine Synthetase; Bioorganic & Medicinal Chemistry Letters 1998, 8, 1629-1634.
Name Reference
4-Amino-4-carboxytetrahydropyran hydrochloride
[217299-03-1]		 36041
4-Amino-4-carboxytetrahydrothiopyran hydrochloride
[67639-41-2]		 36050
4-N-Boc-amino-4-carboxy-1,1-dioxo-tetrahydrothiopyran 36052
4-N-Boc-amino-4-carboxytetrahydropyran
[172843-97-9]		 36046
4-N-Boc-amino-4-carboxytetrahydrothiopyran
[108329-81-3]		 36040

4-N-Fmoc-amino-4-carboxytetrahydrothiopyran

 36049
N-Fmoc-amino-4-(ethylene ketal) cyclohexylcarboxylic acid 36039
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2-Amino-3-piperidin-4-yl propionic acids
2-Amino-3-piperidin-4-yl propionic acids serve as building blocks for piperidinyl-containing protease inhibitors. Adang et al demonstrated (1) the use of 2-amino-3-piperidin-4-yl propionic acid as a component of a new and efficient P1 isostere in the serine protease area.

(1) Adang, A.E. P. et al; Solution-phase and Solid-phase Synthesis of Novel Transition State Inhibitors of Coagulation Enzymes Incorporating a Piperidinyl Moiety; Bioorganic & Medicinal Chemistry Letters 1999, 9, 1227-1232.
Name Reference
2-N-Boc-amino-3-(4-tetrahydropyranyl)propionic acid
[182287-51-0]		 36048
2-N-Boc-amino-3-(4-tetrahydrothiopyranyl)propionic acid 36047
2-N-Fmoc-amino-3-(4-N-Boc-piperidinyl)propionic acid
[313052-02-7]		 36043
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3-Amino-3-arylpropionic acids
3-Amino-3-arylpropionic acids have found therapeutic application in the fields of neuroscience, oncology (1), and virology.

(1) Guillon, J. et al; Synthesis of New Ethyl-3-[3-N’-(2-chloroethyl)-3-N’-nitrosoureido]-3-aryl-propionates as Potential Anticancer Agents; Pharm. Pharmacol. Commun.1998, 4, 231-235.
Name Reference
3-Amino-3-(3-t-butoxyphenyl)propionic acid 36044
3-N-Boc-amino-3-(4-chlorophenyl)propionic acid
[284493-65-8]		 36042
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CHIRAL BUILDING BLOCKS, SCAFFOLDS, AND ADVANCED INTERMEDIATES
Scaffolds
Functionalised Cyclopentanes
Name Reference
(1R,2S,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-14-3]		 36229
(1S,2R,4R)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-23-4]		 36230
(1R,2R,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-16-5]		 36231
(1S,2S,4R)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[262280-14-8]		 36232

(1R,2S,4R)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-17-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36233
(1S,2R,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-21-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36234
(1R,2R,4R)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-18-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36235
(1S,2S,4S)-N-Boc-1-amino-2-hydroxycyclopentane-4-carboxylic acid methyl ester
C12H21NO5
[321744-19-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36236
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Scaffolds
Functionalised Piperidines
Name Reference
(2S,4R)-N-Boc-4-hydroxy piperidine-2-carboxylic acid methyl ester
C12H21NO5		 36200
(2R,4S)-N-Boc-4-hydroxypiperidine-2-carboxylic acid methyl ester
C12H21NO5
[321744-26-7]		 36297
(2S,4S)-N-Boc-4-hydroxy piperidine-2-carboxylic acid benzylamine salt
C18H28N2O5		 36201
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Building Blocks and Advanced Intermediates
Functionalised Cyclopentanes
Name Reference
(1R,4S)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one
C6H7NO
[79200-56-9]		 29704
(1S,4R)-2-Aza-bicyclo[2.2.1]hept-5-en-3-one
C6H7NO
[130931-83-8]		 29705
(1R,2S,3R,4R)-2,3-Dihydroxy-4-(hydroxymethyl)-1-aminocyclopentane hydrochloride
C6H14ClNO3
[79200-57-0]		 36252
(1S,2R,3S,4S)-2,3-dihydroxy-4-(hydroxymethyl)-1-aminocyclopentane hydrochloride
C6H14ClNO3
[220497-88-1]		 36253
(1S,2R,6S,7R)-4,4-Dimethyl-3,5-dioxa-8-aza-tricyclo[5.2.1.02,6]decan-9-one
C9H13NO3
[178032-63-8]		 36220
(1R,2S,6R,7S)-4,4-Dimethyl-3,5-dioxa-8-aza-tricyclo[5.2.1.02,6]decan-9-one
C9H13NO3
[220507-10-8]		 36221
(1S,4R)-2-Aza-bicyclo[2.2.1]heptan-3-one
C6H9NO
[134003-03-5]		 36222
(1S,3R,4S,6R)-N-Boc-6-amino-2,2-dimethyl-tetrahydro-cyclopenta[1.3]dioxole-4-carboxylic acid
C14H23NO6
[220497-93-8]		 36223
(1R,3S,4R,6S)-N-Boc-6-amino-2,2-dimethyl-tetrahydro-cyclopenta[1.3]dioxole-4-carboxylic acid
C14H23NO6
[220497-94-9]		 36224
(1S,4R)-4-Amino-cyclopent-2-ene carboxylic acid
C6H9NO2
[102579-72-6]		 36225
(1R,4S)-4-Amino-cyclopent-2-ene carboxylic acid
C6H9NO2
[134003-04-6]		 36226
(1R,3S)-3-Amino-cyclopentane carboxylic acid
C6H11NO2
[71830-08-5]		 36227

(1S,3R)-3-Amino-cyclopentane carboxylic acid
C6H11NO2
[71830-07-4]

 36228
(R)-4-tert-Butyldimethylsilyloxy-2-cyclopenten-1-one
C11H20O2Si
[61305-35-9]		 36237
(S)-4-tert-Butyldimethylsilyloxy-2-cyclopenten-1-one
C11H20O2Si
[61305-36-0]		 36238
(1R,3R)-N-Boc-3-aminocyclopentane carboxylic acid
C11H19NO4		 36239
(1S,3S)-N-Boc-1-aminocyclopentane-3-carboxylic acid methyl ester
C12H21NO4
[329910-39-6]		 36240
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Building Blocks and Advanced Intermediates
2-Alkyl Succinates
Name Reference
(R)-2-Isopropylsuccinic acid 1-methyl ester
C8H14O4
[220498-08-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36306
(S)-2-Isopropylsuccinic acid 1-methyl ester
C8H14O4
[208113-95-5]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36211
(R)-2-Butylsuccinic acid 1-methyl ester
C9H16O4
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36308
(R)-2-Isobutylsuccinic acid 1-methyl ester
C9H16O4
[130165-76-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36305
(S)-2-Isobutylsuccinic acid 1-methyl ester
C9H16O4
[213270-36-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36210
(R)-2-Cyclohexylsuccinic acid 1-methyl ester
C11H18O4
[220498-07-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36304
(S)-2-Cyclohexylsuccinic acid 1-methyl ester
C11H18O4
[213270-44-1]
Manufactured using DuPont technology under patent EP 0 592 552 B1		 36209
(R)-2-Benzylsuccinic acid 1-methyl ester
C12H14O4
[119807-84-0]
Manufactured using DuPont technology under patent EP 0 592 552 B1		 36302
(S)-2-Benzylsuccinic acid 1-methyl ester
C12H14O4
[182247-45-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36207
(R)-2-(Cyclohexylmethyl)succinic acid 1-methyl ester
C12H20O4
[130165-88-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36303
(S)-2-(Cyclohexylmethyl)succinic acid 1-methyl ester
C12H20O4
[220497-69-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36208
(R)-2-(2-Naphthyl)succinic acid 1-methyl ester
C16H16O4
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36307
(S)-2-(2-Naphthylmethyl)succinic acid 1-methyl ester
C16H16O4
[220497-75-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36213
(S)-2-(1-Naphthylmethyl)succinic acid 1-methyl ester
C16H16O4
[130693-96-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36212
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Building Blocks and Advanced Intermediates
Alcohols
Name Reference
(S)-3-Butyn-2-ol
C4H6O
[2914-69-4]		 36241
(R)-(+)-endo-Norborneol
C7H12O
[36779-79-0]		 36315
(S)-1-Octyn-3-ol
C8H14O
[32556-71-1]		 36243
(R)-1-Octyn-3-ol
C8H14O
[32556-70-0]		 36317
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Building Blocks and Advanced Intermediates
Amines
Name Reference
(S)-Cyclohex-2-enylamine
C6H11N
[153922-89-5]
Manufactured under US patent 5,739,396		 36218
(R)-2-Aminoheptane
C7H17N
[6240-90-0]		 36309
(S)-2-Aminoheptane
C7H17N
[44745-29-1]		 36214
(R)-1-(4-Bromophenyl) ethylamine
C8H10BrN
[45791-36-4]		 36313
(R)-2-Amino-6-methylheptane
C8H19N
[70419-11-3]		 36310
(S)-2-Amino-6-methylheptane
C8H19N
[70419-10-2]		 36215
(R)-2-Amino octane
C8H19N
[34566-05-7]		 36311
(S)-2-Aminooctane
C8H19N
[34566-04-6]		 36216
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Building Blocks and Advanced Intermediates
Amino Acids
Name Reference
(R)-4-Fluorophenylglycine
C8H8FNO2
[93939-74-3]		 36301
(S)-4-Fluorophenylglycine
C8H8FNO2
[19883-57-9]		 36205
(S)-N-3-Cyanophenylalanine
C10H10N2O2
[57213-48-6]		 36206
(R)-3-Amino-3-phenylpropanoic acid ethyl ester hydrochloride salt
C11H16ClNO2
[340188-50-3]		 36299
(S)-3-Amino-3-phenylpropanoic acid ethyl ester hydrochloride salt
C12H15NO2Cl
[167834-24-4]		 36204
(R)-N-Acetyl-2-naphthylalanine
C15H15NO3
[37440-01-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36300
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Building Blocks and Advanced Intermediates
Boc Amino Acids
Name Reference

(S)-N-Boc-azetidine carboxylic acid
C9H15NO4
[51077-14-6]

 36190

(R)-N-Boc-propargylglycine
C10H15NO4
[63039-46-3]

 36285

(S)-N-Boc-propargylglycine
C10H15NO4
[63039-48-5]

 36180

(R)-N-Boc-allylglycine
C10H17NO4
[170899-08-8]

 36284

(S)-N-Boc-allylglycine
C10H17NO4
[170899-08-8]

 36179

(S)-N-Boc-4-thiazoylalanine
C11H16N2O4S
[119434-75-2]

 36178

(1R,4S)-N-Boc-1-aminocyclopent-2-ene-4-carboxylic acid
C11H17NO4
[151907-79-8]

 36181

(1S,4R)-N-Boc-1-aminocyclopent-2-ene-4-carboxylic acid
C11H17NO4
[108999-93-5]

 36182

(1R,3S)-N-Boc-1-aminocyclopentane-3-carboxylic acid
C11H19NO4
[261165-05-3]

 36183

(1S,3R)-N-Boc-1-aminocyclopentane-3-carboxylic acid
C11H19NO4
[161660-94-2]

 36184

(R)-N-Boc-2-(5-bromothienyl)alanine
C12H16BrNO4S
[261380-16-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36277

(S)-N-Boc-2-(5-bromothienyl)-alanine
C12H16BrNO4S
[190319-95-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36170

(R)-N-Boc-2-thienylalanine
C12H17NO4S
[78452-55-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36282

(S)-N-Boc-2-thienylalanine
C12H17NO4S
[56675-37-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36176

(R)-N-Boc-3-thienylalanine
C12H17NO4S
[226880-86-0]
Manufactured under EP 0 592 552 B1 and 5,532,395

 36283

(S)-N-Boc-3-thienylalanine
C12H17NO4S
[56675-37-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36177

(R)-N-Boc-2-furylalanine
C12H17NO5
[261380-18-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36279

(S)-N-Boc-2-furylalanine
C12H17NO5
[145206-40-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36172

(R)-N-Boc-3-pyridylalanine
C13H18N2O4
[98266-33-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36293

(S)-N-Boc-3-pyridylalanine
C13H18N2O4
[117142-26-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36195

(S)-N-Boc-(2-pyridyl)alanine
C13H18N2O4
[71239-85-5]

 36174

(R)-N-Boc-4-pyridylalanine
C13H18N2O4
[37535-58-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36296

(S)-N-Boc-4-pyridylalanine
C13H18N2O4
[37535-57-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36199

(R)-N-Boc-3,4-dichlorophenylalanine
C14H17Cl2NO4
[114873-13-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36294

(S)-N-Boc-3,4-dichlorophenylalanine
C14H17Cl2NO4
[80741-39-5]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36196

(R)-N-Boc-3-amino-3-(4-bromophenyl)propanoic acid
C14H18BrNO4
[261380-20-5]

 36287

(S)-N-Boc-3-amino-3-(4-bromophenyl)propanoic acid
C14H18BrNO4
[261165-06-4]

 36186

(R)-N-Boc-2-bromophenylalanine
C14H18BrNO4
[261360-76-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395

 36274
(S)-N-Boc-2-bromophenylalanine
C14H18BrNO4
[261165-02-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36167
(R)-N-Boc-3-bromophenylalanine
C14H18BrNO4
[261360-77-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36275
(S)-N-Boc-3-bromophenylalanine
C14H18BrNO4
[82278-73-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36168
(R)-N-Boc-4-bromophenylalanine
C14H18BrNO4
[79561-82-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36276
(S)-N-Boc-4-bromophenylalanine
C14H18BrNO4
[62129-39-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36169
(R)-N-Boc-4-chlorophenylalanine
C14H18ClNO4
[57292-44-1
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36292
(S)-N-Boc-4-chlorophenylalanine
C14H18ClNO4
[68090-88-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36194
(S)-N-Boc-3-fluorophenylalanine
C14H18FNO4
[114873-01-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36187
(S)-N-Boc-4-fluorophenylalanine
C14H18FNO4
[41153-30-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36188
(R)-N-Boc-2-fluorophenylalanine
C14H18FNO4
[114873-10-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36290
(S)-N-Boc-2-fluorophenylalanine
C14H18FNO4
[114873-00-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36191
(R)-N-Boc-3-fluorophenylalanine
C14H18FNO4
[114873-11-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36288
(R)-N-Boc-4-fluorophenylalanine
C14H18FNO4
[57292-45-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36443
(R)-N-Boc-4-fluorophenylglycine
C14H18FNO4
[196707-32-1]		 36291
(S)-N-Boc-4-fluorophenylglycine
C14H18FNO4
[142186-36-5]		 36192
(R)-N-Boc-3-amino-3-phenylpropanoic acid
C14H19NO4
[161024-80-2]		 36286
(S)-N-Boc-3-amino-3-phenylpropanoic acid
C14H19NO4
[103365-47-5]		 36185
(R)-N-Boc-4-cyanophenylalanine
C15H18N2O4
[146727-62-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36289
(S)-N-Boc-4-cyanophenylalanine
C15H18N2O4
[131724-45-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36189
(S)-N-Boc-3-cyanophenylalanine
C15H18N2O4
[131980-30-8]		 36193
(R)-N-Boc-(5-bromo-2-methoxyphenyl)alanine
C15H20BrNO5
[261380-17-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36278
(S)-N-Boc-(5-bromo-2-methoxyphenyl)alanine
C15H20BrNO5
[261165-03-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36171
(2S,3R)-N-Boc-2-amino-3-phenylbutyric acid
C15H21NO4
[145432-51-5]		 36203
(R)-N-Boc-styrylalanine
C16H21NO4
[261380-19-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36281
(S)-N-Boc-styrylalanine
C16H21NO4
[261165-04-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36175
(R)-N-Boc-2-naphthylalanine
C18H21NO4
[76985-10-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36280
(S)-N-Boc-2-naphthylalanine
C18H21NO4
[58438-04-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36173
(R)-N-Boc-1-naphthylalanine
C18H21NO4
[76932-48-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36295
(S)-N-Boc-1-naphthylalanine
C18H21NO4
[55447-00-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36198
[ back to products list ]
Building Blocks and Advanced Intermediates
Fmoc Amino Acids
Name Reference
(R)-N-Fmoc-azetidine-2-carboxylic acid
C19H17NO4		 36268
(S)-N-Fmoc-azetidine-2-carboxylic acid
C19H17NO4
[136552-06-2]		 36160
(R)-N-Fmoc-propargylglycine
C20H17NO4		 36262
(S)-N-Fmoc-propargylglycine
C20H17NO4
[198561-07-8]		 36150
(R)-N-Fmoc-(2-bromoallyl)glycine
C20H18BrNO4
[220497-92-7]		 36260
(S)-N-Fmoc-(2-bromoallyl)-glycine
C20H18BrNO4
[220497-60-9]		 36147
(R)-N-Fmoc-allylglycine
C20H19NO4
[170642-28-1]		 36259
(S)-N-Fmoc-allylglycine
C20H19NO4
[146549-21-5]		 36146
(R)-N-Fmoc-4-thiazoylalanine
C21H18N2O4S
[205528-33-2]		 36258
(S)-N-Fmoc-4-thiazoylalanine
C21H18N2O4S
[205528-32-1]		 36145
(1R,4S)-N-Fmoc-1-aminocyclopent-2-ene-4-carboxylic acid
C21H19NO4
[220497-65-4]		 36151
(1S,4R)-N-Fmoc-1-aminocyclopent-2-ene-4-carboxylic acid
C21H19NO4
[220497-64-3]		 36152
(1R,3S)-N-Fmoc-1-aminocyclopentane-3-carboxylic acid
C21H21NO4
[220497-66-5]		 36153
(1S,3R)-N-Fmoc-1-aminocyclopentane-3-carboxylic acid
C21H21NO4
[220497-67-6]		 36154
(R)-N-Fmoc-2-(5-bromothienyl)alanine
C22H18BrNO4S
[220497-83-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36248
(S)-N-Fmoc-2-(5-bromothienyl)-alanine
C22H18BrNO4S
[220497-50-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36138
(R)-N-Fmoc-2-thienylalanine
C22H19NO4S
[201532-42-5]
Manufactured under P 0 592 552 B1 and US 5,532,395		 36256
(S)-N-Fmoc-2-thienylalanine
C22H19NO4S
[130309-35-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36143
(R)-N-Fmoc-3-thienylalanine
C22H19NO4S
[220497-90-5]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36257
(S)-N-Fmoc-3-thienylalanine
C22H19NO4S
[186320-06-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36144
(R)-N-Fmoc-(2-furyl)alanine
C22H19NO5
[220497-85-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36249
(S)-N-Fmoc-(2-furyl)alanine
C22H19NO5
[159611-02-6]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36139
(R)-N-Fmoc-4-fluorophenylglycine
C23H18FNO4		 36270
(S)-N-Fmoc-4-fluorophenylglycine
C23H18FNO4		 36161
(R)-N-Fmoc-3-pyridylalanine
C23H20N2O4
[142994-45-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36273
(R)-N-Fmoc-(2-pyridyl)-alanine
C23H20N2O4
[185379-39-9]		 36254
(S)-N-Fmoc-(2-pyridyl)-alanine
C23H20N2O4
[185379-40-2]		 36141
(S)-N-Fmoc-3-pyridylalanine
C23H20N2O4
[175453-07-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36164
(R)-N-Fmoc-3-amino-3-(4-bromophenyl)propanoic acid
C24H20BrNO4
[220498-04-4]		 36264
(S)-N-Fmoc-3-amino-3-(4-bromophenyl)propanoic acid
C24H20BrNO4
[220497-68-7]		 36156
(R)-N-Fmoc-2-bromophenylalanine
C24H20BrNO4
[220497-79-0]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36245
(S)-N-Fmoc-2-bromophenylalanine
C24H20BrNO4
[220497-47-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36134
(R)-N-Fmoc-3-bromophenylalanine
C24H20BrNO4
[220497-81-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36246
(S)-N-Fmoc-3-bromophenylalanine
C24H20BrNO4
[220497-48-3]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36136
(R)-N-Fmoc-4-bromophenylalanine
C24H20BrNO4
[198545-76-5]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36247
(S)-N-Fmoc-4-bromophenylalanine
C24H20BrNO4
[198561-04-5]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36137
(R)-N-Fmoc-4-chlorophenylalanine
C24H20ClNO4
[142994-19-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36272
(S)-N-Fmoc-4-chlorophenylalanine
C24H20ClNO4
[175453-08-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36163
(R)-N-Fmoc-2-fluorophenylalanine
C24H20FNO4
[198545-46-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36269
(S)-N-Fmoc-2-fluorophenylalanine
C24H20FNO4
[205526-26-7]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36251
(R)-N-Fmoc-3-fluorophenylalanine
C24H20FNO4
[198545-72-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36265
(S)-N-Fmoc-3-fluorophenylalanine
C24H20FNO4
[198560-68-8]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36157
(R)-N-Fmoc-4-fluorophenylalanine
C24H20FNO4
[177966-64-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36266
(S)-N-Fmoc-4-fluorophenylalanine
C24H20FNO4
[169243-86-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36158
(S)-N-Fmoc-3-amino-3-(3-nitrophenyl)propanoic acid
C24H20N2O6
[206060-42-6]		 36165
(R)-N-Fmoc-3-amino-3-phenylpropanoic acid
C24H21NO4
[220498-02-2]		 36263
(S)-N-Fmoc-3-amino-3-phenylpropanoic acid
C24H21NO4
[209252-15-3]		 36155
(S)-N-Fmoc-2-amino-2-cyclohexyl-propanoic acid
C24H27NO4
[135673-97-1]
Manufactured under US patent 5,739,396		 36148
(R)-N-Fmoc-3-cyanophenylalanine
C25H20N2O4
[205526-37-0]		 36271
(S)-N-Fmoc-3-cyanophenylalanine
C25H20N2O4
[205526-36-9]		 36162
(R)-N-Fmoc-4-cyanophenylalanine
C25H20N2O4
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36267
(S)-N-Fmoc-4-cyanophenylalanine
C25H20N2O4
[173963-93-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36159
(R)-N-Fmoc-octylglycine
C25H31NO4
[220497-96-1]		 36261
(S)-N-Fmoc-octylglycine
C25H31NO4
[193885-59-5]		 36149
(R)-N-Fmoc-styrylalanine
C26H23NO4
[215190-23-1]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36255
(S)-N-Fmoc-styrylalanine
C26H23NO4
[159610-82-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36142
(S)-N-Fmoc-1-naphthylalanine
C28H23NO4
[96402-49-2]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36166
(R)-N-Fmoc-2-naphthylalanine
C28H23NO4
[138774-94-4]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36250
(S)-N-Fmoc-2-naphthylalanine
C28H23NO4
[112883-43-9]
Manufactured under EP 0 592 552 B1 and US 5,532,395		 36140
[ back to products list ]
Building Blocks and Advanced Intermediates
Amino Alcohols
Name Reference
(R)-3-Amino-3-phenylpropan-1-ol
C9H13NO
[170564-98-4]		 36312
(S)-3-Amino-3-phenyl propan-1-ol
C9H13NO
[82769-76-4]		 36217
(R)-2-Aminobut-3-en-1-ol , benzoate salt
C11H15NO3
Manufactured under US patent 5,739,396		 36316
(S)-2-Aminobut-3-en-1-ol, benzoate salt
C11H15NO3
[261360-75-2]
Manufactured under US patent 5,739,396		 36242
(R)-N-Phthaloyl-2-aminobut-3-en-1-ol
C12H11NO3
[174810-06-1]
Manufactured under US patent 5,739,396		 36318
[ back to products list ]
Building Blocks and Advanced Intermediates
Diols
Name Reference
(2R,5R)-2,5-hexanediol
C6H14O2
[17299-07-9]		 36320
(3R,6R)-3,6-octanediol
C8H18O2
[129619-37-0]		 36321
(3S,6S)-3,6-octanediol
C8H18O2
[136705-66-3]		 36322
[ back to products list ]
Building Blocks and Advanced Intermediates
Halo Acids
Name Reference
(R)-5-Phthalimido-2-bromovaleric acid
C13H12BrNO4
[179090-36-9]		 36319


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