Advanced Technology And Industrial Co., Ltd
Catalogue - Novelties
Boronic acids and derivatives

 

Arylboronic acids and their esters are highly popular synthetic intermediates in organic synthesis both for their ease of conversion to other functional groups (such as phenols1 and aryl halides2) and to their efficient Pd-catalyzed coupling with aryl or vinyl halides or triflates to form biaryl and alkyl aryl derivatives.3,4,5,6,7
The latter transformation, the Suzuki coupling reaction, offers a significant enhancement (easy aqueous workup, low toxicity and environmental impact, compatibility with electrophilic susbtituents, air stability, and low cost) to the previous routes for the preparation of such C-C coupled products, which involved the coupling of organometallic reagents with aryl halides. In addition, there has been a wealth of recent examples further extending the utility and scope of the Suzuki reactions such as the preparation of heterocyclic compounds8 and the introduction of alkoxycarbonyl-protected b-aminoethyl groups into arenes and alkenes.9
Acros Organics has recently expanded its selection of boronic acids to include a wide variety of highly functionalised alkyl and arylboronic acids. These products are sorted in the next pages as follows:

  1. Aromatic Boronic Acids
    • Phenyl Derivatives
    • Pyridyl Derivatives,
    • Thiophene Derivatives
    • Furan Derivatives
    • Others
  2. Alkyl Boronic Acids
  3. Other Boronic Acids

Within each of the above sub families, products are listed alphabetically. If the product of your choice is not listed or if you require larger quantities please inquire.

References:

1. Webb, K. S. and Levy D. Tetrahedron Lett. 1995, 36, 5117.
2. Thiebes, C. T.; Surya Prakash, G. K.; Petasis, N. A.; Olah, G. Synlett 1998, 141.
3. Suzuki, A. Pure Appl. Chem. 1994, 66, 213.
4. Suzuki, A. in Metal Catalyzed Cross-coupling Reactions, Diederich, F. and Stang, P. J., Ed.; Wiley-VCH: New York, 1998, pp.49-97.
5. Miyaura, N. and Suzuki, A. Chem. Rev. 1995, 95, 2457-2483.
6. Suzuki, A. J. Organometallic Chem. 1999, 576, 147-168.
7. Miyaura, N.; Ishiyama, T.; Sasaki, H.; Ishikawa, M.; Satoh, M.; Suzuki, A. J. Am. Chem. Soc. 1989, 111, 314-321.
8. Occhiato, E. G.; Trabocchi, A.; Guarna, A. J. Org.Chem. 2001, 66(7), 2459-2465.
9. Kamatani, A. and Overman, L. E. J. Org. Chem. 1999, 64, 8743-8744.

List of products
Name Reference
AROMATIC BORONIC ACIDS - PHENYL DERIVATIVES
2-Acetylphenylboronic acid 35882
3-Acetylphenylboronic acid 35883
4-Aminomethylphenylboronic acid HCl 35884
3-Aminophenylboronic acid monohydrate, 98% 35276
3-Aminophenylboronic acid hemisulfate 10430
Benzene-1,4-diboronic acid 35885
3-Benzyloxybenzeneboronic acid 35886
4-Benzyloxybenzeneboronic acid 35887
Biphenyl-3-boronic acid 35888
3,5-Bis(trifluoromethyl)benzeneboronic acid 35136
4-Borono-DL-phenylalanine 35890
4-Borono-L-phenylalanine 35893
4-Borono-D-phenylalanine 35892
3-Bromophenylboronic acid 35894
4-Bromophenylboronic acid 10728
4-tert-Butylbenzeneboronic acid 35897
3-Carboxyphenylboronic acid 34463
4-Carboxyphenylboronic acid, 97% 34440
2-Chlorophenylboronic acid 35899
3-Chlorophenylboronic acid 35900
4-Chlorophenylboronic acid, 97% 34441
3-Cyanophenylboronic acid 35903
4-Cyanophenylboronic acid 35904
Dibenzofuran-4-boronic acid 35907
Dibenzothiophene-4-boronic acid 35908
2,6-Dichlorophenylboronic acid 35911
3,4-Dichlorophenylboronic acid 35909
2,3-Difluorophenylboronic acid 35912
2,5-Difluorophenylboronic acid 35914
2,4-Difluorophenylboronic acid 35913
2,6-Difluorophenylboronic acid 35915
3,5-Difluorophenylboronic acid 35917
2-(4-Dihydroxyborane)phenyl-4-carboxy-6-methylquinoline 35918
2-(4-Dihydroxyborane)phenyl-4-carboxyquinoline 35919
2,4-Dimethoxybenzeneboronic acid 35920
2,5-Dimethoxyphenylboronic acid 35921
2,6-Dimethoxyphenylboronic acid 35922
2-(N,N-Dimethylaminomethyl)phenylboronic acid 35924
4-(N,N-Dimethylamino)phenylboronic acid 35923
2,6-Dimethylphenylboronic acid 35927
3,4-Dimethylphenylboronic acid 35928
3,5-Dimethylphenylboronic acid 35929
3-Ethoxycarbonylphenylboronic acid 35930
4-Ethoxyphenylboronic acid 35931
4-Ethylphenylboronic acid 35932
2-Fluorophenylboronic acid 35934
3-Fluorophenylboronic acid, 97% 34564
4-Fluorophenylboronic acid 33410
2-Formylphenylboronic acid 35936
3-Formylphenylboronic acid 35937
4-Formylphenylboronic acid 35938
4-Hydroxyphenylboronic acid 2-tetrahydropyranyl ether 35945
5-Indolylboronic acid 35946
4-Iodophenylboronic acid 35948
3-Iodophenylboronic acid 35947
3-Isopropoxycarbonylphenylboronic acid 35950
4-(Methanesulfonyl)phenylboronic acid 35951
4-Methoxycarbonylphenylboronic acid 35956
4-Methoxy-2-formylphenylboronic acid 35952
5-Methoxy-2-formylphenylboronic acid 35953
2-Methoxy-5-formylphenylboronic acid 35954
3-Methoxyphenylboronic acid 35957
2-Methoxyphenylboronic acid, 97% 34466
4-Methoxyphenylboronic acid, 97% 30948
3,4-Methylenedioxyphenylboronic acid 35958
4-(Methylthio)phenylboronic acid, 97% 34468
1-Naphthaleneboronic acid, 97% 34469
Naphthalene-2-boronic acid 35962
3-Nitrophenylboronic acid, 97% 34470
Phenoxathiin-4-boronic acid 35963
4-Phenoxyphenylboronic acid 35964
Phenylboronic acid, 98+% 13036
8-Quinoline boronic acid 35967
Thianthrene-1-boronic acid 35969
3-Thioanisoleboronic acid 35970
2-Tolylboronic acid, 95% 30926
3-Tolylboronic acid, 97% 34442
4-Tolylboronic acid, 97% 34443
2,4,6-Trichlorophenylboronic acid 35971
3-Trifluoromethoxyphenylboronic acid 35972
4-Trifluoromethoxyphenylboronic acid 35973
2-Trifluoromethylphenylboronic acid 35974
3-Trifluoromethylphenylboronic acid 35975
4-Trifluoromethylphenylboronic acid 35976
4-(Trimethylammonium)methylphenylboronic acid 35978
2,4,6-Trimethylphenylboronic acid 35979
AROMATIC BORONIC ACIDS - PYRIDYL DERIVATIVES
2-Methoxy-5-pyridineboronic acid 35955
Pyridine-3-boronic acid 35965
Pyridine-4-boronic acid 35966
AROMATIC BORONIC ACIDS - THIOPHENE DERIVATIVES
2-Benzothienylboronic acid 35891
5-Bromothiophene-2-boronic acid 35896
5-Chlorothiophene-2-boronic acid 35901
4-Methylthiophene-2-boronic acid 35960
5-Methylthiophene-2-boronic acid 35961
2-Thiopheneboronic acid 34471
3-Thiopheneboronic acid, 97% 34566
AROMATIC BORONIC ACIDS - FURAN DERIVATIVES
2-Formylfuran-5-boronic acid 35935
Furan-2-boronic acid 35939
Furan-3-boronic acid 35940
5-Methylfuran-2-boronic acid 35959
AROMATIC BORONIC ACIDS – OTHERS
1-tert-Butoxycarbonyl-2-pyrrolylboronic acid 35898
3,5-Dimethylisoxazole-4-boronic acid 35925
ALKYL BORONIC ACIDS
n-Butylboronic acid, 98% 17238
n-Hexylboronic acid 34465
(2-Methylpropyl)boronic acid 35995
trans-b-Styreneboronic acid 35968
OTHER BORONIC ACIDS
Bis(neopentyl glycolato)diboron 35889
Bis(pinacolato)diboron, 98% 33057
2-Isopropoxy-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane 35949
Tris(dimethylamino)borane 35980


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