Cyclopropane carboxylic acids and derivatives

Cyclopropane aminoacids are defined as alpha-aminoacids with a bridging methylene group forming a cyclopropyl ring. Such compounds are of interest as natural products, and also as conformationally-restricted analogues of the proteinogenic aminoacids. It is therefore of great interest to incorporate them in peptides in order to probe conformational spaces and reactivity.

A wealth of publications covering the chemistry of cyclopropane aminoacids is available today including an excellent review by Stammer⁽ⁱ⁾. We have recently introduced the Boc-protected cyclopropane aminoacids listed below.

Additional cyclopropane carboxylic acids and derivatives from Acros Organics A large selection of other cyclopropane carboxylic acids and derivatives can be found in our product range and are listed below. Please inquire if the product of your interest is not listed.
Name	Reference
Cyclopropanecarboxylic acid	11162
Cyclopropanecarboxylic acid chloride	11163
1,1-Cyclopropanedicarboxylic acid	34528
Ethyl cyclopropanecarboxylate	11835
Methyl cyclopropanecarboxylate	12671
trans-2-Phenylcyclopropane-1-carboxylic acid	13046
1-(2,4-Dichlorophenyl)cyclopropanecarboxylic acid	13492
Diethyl 1,1-cyclopropanedicarboxylate	16445
1-Phenyl-1-cyclopropanecarbonitrile	17059
1-Phenyl-1-cyclopropanecarboxylic acid	17068
1-(4-Chlorophenyl)-1-cyclopropanecarboxylic acid	17069
2-Methylcyclopropanecarboxylic acid	19816
DL-3-Methylenecyclopropane-trans-1,2-dicarboxylic acid	20529
Dimethyl cis-1,2-cyclopropanedicarboxylate	25534
Dimethyl 1-methyl-trans-1,2-cyclopropanedicarboxylate	27850
Dimethyl 3-methyl-trans-1,2-cyclopropanedicarboxylate	27851
1-Amino-1-cyclopropanecarboxylic acid	30142
1-Hydroxy-1-cyclopropanecarboxylic acid	30143
Methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl- (1-cyclopropane)carboxylate, cis/trans	23305
Methyl (1R,3S)-2,2-dimethyl-3-(2-oxopropyl)-cyclopropaneacetate	27520
Methyl 1-hydroxy-1-cyclopropane carboxylate	30211
1-(Aminocarbonyl)-1-cyclopropanecarboxylic acid	30963
Ethyl 1-hydroxycyclopropanecarboxylate	33530