Solid Phase Synthesis

The use of polymer supports in organic synthesis is becoming well established as demonstrated by the massive increase in the number of publications referring to it. The key reported advantages for solid-phase synthesis being faster and simplified procedures for the generation of a large number of compounds (use of automation/ ease of purification of intermediates and products/ use of excess starting material). At Acros Organics, we understand that for a solid phase synthesis procedure to fulfill its advantageous promises, it is crucial to select the correct resin matrix and linker(s) for the reaction under consideration.

Selection
Most chemistry using solid-supported synthesis reported today uses polystyrene cross-linked with 1-2% divinyl benzene (DVB) as the resin matrix. Such resins are stable and exhibit high compatibility and good swelling characteristics with a wide range of non polar solvents; however, they fail when polar solvents are required and distancing of the reaction sites from the hydrophobic PS-DVB resin core becomes necessary. For such reactions, TentaGel®, a polystyrene/divinylbenzene - poly (ethylene glycol) graft copolymer that swells in a wide variety of polar and non-polar solvents is highly popular.

Linkers provide attachment sites for different functional groups onto the resin and their proper choice is crucial for a solid phase synthesis to be successful. Access to a wide variety of linkers is key to allow for flexibility in the design of polymer-supported chemical reactions.

Acros Organics Offer
A selection of polystyrene and TentaGel® resins for solid phase synthesis with a broad variety of linker groups and narrow-range loading capacities has been recently introduced to our stock. This selection is presented in this publication with a sampling of references to the chemistry of some of its entries. The resins are offered to customers with our assurance of accurate, consistent, and reproducible specifications at highly competitive prices. The introduction of additional resins for synthesis as well as solid-supported scavengers and reagents is underway.

Developments within this field are fast and we are working on keeping up the pace to meet our customers’ needs. Please check our website or contact your nearest Acros Organics distributor for additional entries or bulk inquiries.

Solution Phase Synthesis

Solution phase synthesis, where a reactive, functional group specific scavenger, a reagent, a ligand, or catalyst is attached to a polymer support, has been a fast growing area of synthesis.

This methodology takes advantage of new developments within the field of solid phase synthesis and adapts them to the existing vast repertoire of chemical reactions. Excellent publications detailing the utility, limitations, and current status of solution phase chemistry research are available.⁽ⁱ⁾

A wide range of resins for solution-phase synthesis have been introduced to Acros Organics to respond to the needs of the organic chemist adopting solution-phase strategies in his synthesis.

(i) Carmen M. Baldino; J. Comb. Chem. 2000; 2 (2), 89 -103.