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In its simplest form, micromanipulation is best described as the co-ordinated movement of a tool; in x, y and z direction using mechanical, hydraulic or electric devices with a resolution of up to 1.0 micrometre.

Four main areas of Micromanipulation dominate, IVF, Electrophysiology, Transgenics and Adherent Cell Microinjection.

Merck Eurolab is the major distributor for the highest quality Micromanipulaters from Eppendorf. Each Micromanipulation variant and ancillary product is packed with benefits backed by Eppendorf's legendary reliability.

Merck Eurolab is able to place Micromanipulaters onto the vast majority of microscopes due to the flexibility of the adapters and dexterity of the motor units.

In house specialists support the business throughout the UK with expert knowledge and practical know how.

Merck Eurolab’s excellent relationships with all four major microscope manufacturers makes it unique in being able to offer you the system of your choice.

Patchman offers new dimensions for micromanipulation in the field of electrophysiology. Electronic stepper motors supported by a micro-processor allow a coarse and fine manipulator to be combined in one device. Both resolution ranges can be adapted to your individual needs, thus ensuring rapid and precise positioning, regardless of whether you require high resolution, rapid electrode exchange or axial movements.

Thanks to optional software ECETPARM, the basic parameters (speed for coarse and fine manipulation, offset distances when returning from the Home position, resolution of the single step mode) can be programmed, stored as individual files and then selected as required. Patchman therefore allows the human/machine interface to be individually programmed. A joystick allows ergonomic, centralised operation of the X, Y and Z axis of the manipulator. Thanks to an intuitive four-key operating panel, additional functions are available at the push of a button:

• Switch between coarse and fine resolution
• Choice between dynamic mode and single step resolution
• Coupling with the X and Z axis for programming axial movement
• Automatic electrode movement (Home function) for easy electrode exchange
• Joystick inactivation for interference-free measurement

The facts of the matter are clear: Patchman is your perfect partner for patch clamping.

For more information on Advacnced please email sales@advtechind.com
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The term "transgenic animals" describes animals whose chromosomes contain stably integrated copies of genes or gene constructs derived from other species or not normally found in the host animal. For this reason mice, rats or other small mammals are used to introduce foreign DNA into oocytes or embryos (blastocysts). Two different techniques can be used.

Both techniques can be easily performed with the Eppendorf Micromanipulator TransferMan, CellTram Air, CellTram Oil and the Transjector. The automation of repetitive tasks while maintaining easy operation allows the user to concentrate on the micromanipulations themselves. This enables rapid work with good results. The capilliaries cannot be moved unintentionally by the user, which guarantees optimum protection of the sensitive embryos or blastocysts.

For more information on micromanipulation products please email msgroup@merckeurolab.ltd.uk or contact our literature request line on 01202 664421.

37° Incubation Chambers

This transparent environmental chamber is designed for use with Research Inverted Microscopes and Confocal Microscopes. Many research laboratories are using these incubation chambers for prolonged studies of living cells, including time lapse image capture experiments for cell motility and cell death, which may be carried out at elevated temperatures.

Micro-manipulation of living cells can also take place in this temperature controlled environment. Warm, filtered air circulates within the acrylic chamber from a heater unit that is mechanically isolated from the environmental chamber. This ensures that there is no transmission of vibration from the heater fan to the microscope. Users may select temperatures within the range 32°C* to 42°C. An optional warm stage enhances temperature control. Two doors allow specimens to be changed and the condenser settings to be adjusted. A further two doors, below the stage, allow access to the nosepiece and objectives. Focusing and stage controls remain outside the environmental chamber. The 35mm camera, video camera, multi-viewing and fluorescence capabilities of the microscope are unaffected. Filter wheels, motorised stages, micro-manipulators and auto focusing accessories can also be accommodated. The chamber can, when required, be quickly removed without the use of hand tools.

* or ambient +10°C, whichever is greater

A CO2 enriched environment extends the life of the growth medium during prolonged experiments. A precision needle valve controls the flow of CO2 or CO2 mixture through a water reservoir. This both humidifies the gas and gives a simple, visual indication of flow. The supply of water can be topped up during prolonged experiments. Tools are provided to simplify the gas feed through a sterile filter and a luer needle into the chamber.

The temperature(s) registered by platinum foil sensors located in the environmental chamber and the optional warm stage may be logged for the duration of the experiment. Connection is made from the RS485 port of the temperature controller(s) to the serial port on an IBM Compatible PC. This Windows 95® software runs in the background of the image capture/analysis software.

For further details please call our literature request email sales@advtechind.com
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Microinjection into adherent cells requires the utmost precision in the range of nanometers and femtoliters.

Micromanipulators are unable to co-ordinate the movement of the injection capillary with the injection process and are rarely suitable for these applications.

The tried and tested solution is semi-automatic microinjection using the universal Micromanipulator 5171 and the programmable microinjector Transjector 5246.

Semi-automatic microinjections become even easier thanks to InjectMan, the new, advanced specialist micromanipulator. It is easy to operate allowing you to concentrate fully on your microinjections. You can define the injection plane, use the joystick to move the injection capillary to a position above the cell and simply press the injection key without even having to look up from the microscope.

Simultaneously, InjectMan triggers a patented axial injection movement and a programmable pressure increase in the Transjector. Due to the precision of the injection movement, your sensitive cells have a high survival rate. The electronic connection between Transjector and InjectMan guarantees simple, rapid and reproducible microinjections into cells. Another innovative feature is that the angle of injection is adjustable in the axial direction, facilitating complex injection tasks and eliminating space problems at the microscope. InjectMan and Transjector form a perfectly tuned team for precise, rapid, uncomplicated and versatile microinjection.

For more information on InjectMan and Transjector please email sales@advtechind.com
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Intracytoplasmic spermatocyte injection (ICSI) can now be found in many laboratories around the globe. This has caused growing demand for routine instrumentation. Automation of repetitive tasks while maintaining easy operation will be the future benchmark.

Two pressure control systems, CellTram Air and CellTram Oil, and Eppendorf capillaries VacuTip and TransferTip (ICSI) complement TransferMan making it the perfect ICSI workstation.

The decisive advantages:

For more information on the Micromanipulator TransferMan and the Microinjector CellTram please email: sales@advtechind.com .
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