| Identifiers |
 |
| Product Name |
Beta-Secretase Inhibitor II |
| Catalogue No. |
CM261719 |
|
Description |
A potent, cell permeable and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC₅₀ = 700 nM) and Aβ1-42 (IC₅₀ = 2.5 µM) in CHO cells stably transfected with wild-type APP751. |
|
Application |
1 mg. A potent, cell permeable, and reversible inhibitor of beta-secretase that corresponds to the beta-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Atotal (IC50 = 700 nM) and A1-42 (IC50 = 2.5 uM) in CHO cells stably transfected with wild-type APP751. |
| Formula |
C₂₅H₃₉N₃O₅ |
| MW |
461.6 |
| Storage
Condition |
-20°C |