| Identifiers | ||
| Product Name | Chk2 Inhibitor | |
| Catalogue No. | CM726664 | |
| Description | A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC₅₀ = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC₅₀ = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC₅₀ of 3 µM and 7.6 µM, respectively. | |
| Application | 1 mg Chk2 Inhibitor, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide. Purity:>98% by HPLC. CAS#516480-79-8 ; A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC50 = 15 nM; Ki = 37 nM). Displays ~1,000-fol | |
| CAS Number | 516480-79-8 | |
| Formula | C₂₀H₁₄CIN₃O₂ | |
| MW | 363.8 | |
| Storage Condition | -20°C | |
| Brand | Packing | Pricing | Quote request |
| IL | 1 mg | Inquiry | Ask Quote |
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